Studies of the Association between the Kynurenine-3-Monooxygenase Gene and Depression
| Autor: | Vera Golimbet, T. V. Lezheiko, A. E. Melik-pashayan, E. V. Mironova, A. V. Andryushchenko |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry General Neuroscience Healthy subjects 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology Kynurenic acid chemistry Polymorphism (computer science) Internal medicine Genotype medicine In patient business Gene Kynurenine 3-Monooxygenase 030217 neurology & neurosurgery Depression (differential diagnoses) |
| Zdroj: | Neuroscience and Behavioral Physiology. 48:416-419 |
| ISSN: | 1573-899X 0097-0549 |
| Popis: | Objective. To study the association between the kynurenine-3-monooxygenase (KMO) gene and depression. Materials and methods. Polymorphic loci rs2275163 (C/T) and rs1053230 (A/G) of the KMO gene were studied in patients with depression (study group) and mentally healthy subjects of comparable gender and age (control group). Results and conclusions. The rs2275163 polymorphism was not associated with depression. An association between the rs1053230 polymorphism and depression was found. The frequency of the GG genotype, linked with lower KMO activity and increased kynurenic acid levels in patients with endogenous psychoses, was greater in the study group than the control group (p = 0.001, OR 2.8 (95% CI 1.73–4.24). thus, the GG genotype can be regarded as a risk allele for developing depression. |
| Databáze: | OpenAIRE |
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