Synthesis of Rovafovir Etalafenamide (Part II): Dynamic Control for Successful Scale-Up of an Oxygen-Releasing Elimination Reaction Mediated by Oxone

Autor:	Nande Wright, Roberts Benjamin James, Bernard Kwong, Keshab Sarma, Smith Mark, Alan Scott Triman, Elan Shao, Jason A. Davy, Andrew Anthony Martins, Jinyu Shen, Brandon Heath Brown, Dustin Bringley, Keiko Sujino, Selcuk Calimsiz, Detian Gao
Rok vydání:	2021
Předmět:	010405 organic chemistry Organic Chemistry Ph control chemistry.chemical_element Dynamic control Oxidative phosphorylation 010402 general chemistry 01 natural sciences Oxygen Combinatorial chemistry 0104 chemical sciences Elimination reaction chemistry SCALE-UP Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 25:1237-1246
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.0c00439
Popis:	As part of the synthesis of rovafovir etalafenamide, the development and manufacturing-scale demonstration of a dioxirane-mediated oxidative elimination is described. The reaction presented multipl...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::716ab3ca237293fc9365771f045b76d4 https://doi.org/10.1021/acs.oprd.0c00439 Zobrazit plný text záznamu