The Catalytic Reaction Mechanism of the β-Galactocerebrosidase Enzyme Deficient in Krabbe Disease
| Autor: | Alba Nin-Hill, Carme Rovira |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry General Chemistry 010402 general chemistry medicine.disease Car–Parrinello method Cleavage (embryo) 01 natural sciences Catalysis 0104 chemical sciences Enzyme Biochemistry Krabbe disease medicine Glycoside hydrolase β galactocerebrosidase |
| Zdroj: | ACS Catalysis. 10:12091-12097 |
| ISSN: | 2155-5435 |
| DOI: | 10.1021/acscatal.0c02609 |
| Popis: | Krabbe disease is a neurodegenerative disorder related to misfunction of β-galactocerebrosidase (GALC), a glycosidase that cata-lyzes the cleavage of β-galactosidic bonds in glycosphingolipids. Her... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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