One-pot synthesis of β-imidazolylpropionamides

Autor:	Andrey A. Tolmachev, Pavel V. Khodakovskiy, Sergey V. Ryabukhin, Alexander N. Shivanyuk, Dmitry S. Granat
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Acylation chemistry.chemical_compound Double bond chemistry Organic Chemistry Drug Discovery One-pot synthesis Imidazole Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 49:3997-4002
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2008.04.096
Popis:	New efficient one-pot methodology for the preparative synthesis of β-imidazolylpropionamides was elaborated. It is based on the addition of imidazole to the activated double bond of the intermediate acrylimidazolide in the reaction between diverse acrylic acids and different amines promoted by CDI. A set of structurally and functionally diverse β-imidazolylpropionamides was obtained in high preparative yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7165a0e2f4d84ac4c170e28462ea3ca3 https://doi.org/10.1016/j.tetlet.2008.04.096 Zobrazit plný text záznamu Full Text from ScienceDirect