DNA damage protecting activity andin vitroantioxidant potential of the methanol extract ofCyclotrichium niveum
| Autor: | Murat Kizil, Sevil Emen, Göksel Kızıl, Bircan Çeken |
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| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Antioxidant Chemistry DNA damage DPPH medicine.medical_treatment Pharmaceutical Science General Medicine Protein oxidation Lipid peroxidation chemistry.chemical_compound Complementary and alternative medicine Biochemistry Drug Discovery medicine Molecular Medicine Chelation Gallic acid Food science IC50 |
| Zdroj: | Pharmaceutical Biology. 47:219-229 |
| ISSN: | 1744-5116 1388-0209 |
| Popis: | Cyclotrichium niveum (Boiss.) Manden. & Scheng., a herb of the Labiate family, has been widely used as a flavoring agent in Turkey; it was examined for its antioxidant potential and DNA damage protecting activity. The antioxidant activity of C. niveum aerial parts (stems, leaves, and flowers) was determined from the methanol extract. The antioxidant potency of methanol extract of C. niveum was investigated employing various established in vitro systems, such as lipid peroxidation in rat brain homogenate, 1,1- diphenyl-2-picrylhydrazyl (DPPH), hyrdoxyl radical scavenging, reducing power, iron chelation, and inhibitory effect on protein oxidation. The methanol extract of C. niveum was able to reduce the stable free radical DPPH with an IC50 of 78.15 μg/mL. The metal chelating ability was found to be low compare with EDTA. Methanol extract of C. niveum aerial parts showed strong inhibitory activity toward lipid peroxidation of rat brain homogenate induced by the FeCl2-H2O2 system. Furthermore, C. niveum extr... |
| Databáze: | OpenAIRE |
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