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Seven isopimarane diterpenoids have been isolated from Nepeta septemcrenata (3) and Lycopus europaeus (4–9), both species belonging to the Labiatae family. Compound 3 had been reported as the sole diterpene constituent of N. septemcrenata, whereas the physical and spectroscopic data of 4 were identical to those of a compound previously isolated from L. europaeus to which structure 1 had been attributed. As a result of exhaustive spectroscopic studies and some chemical correlations between 3 and 4, we definitely conclude that structure 1 must be amended to 4. In addition, the structures of five new diterpenoids found in L. europaeus (5–9) were established by chemical and spectroscopic means, and a normal isopimarane absolute configuration for all the isolated compounds, except for 7, was supported by CD data, application of the Horeau's method and chemical correlations. |
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