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Background: Refeeding syndrome (RFS) was a group of metabolic disorders associated with refeeding after starvation. However, RFS is underdiagnosed in China due to the highly heterogeneous diagnostic criteria. This study was to evaluate the diagnosis of RFS in our intensive care unit (ICU).Methods: Patients monitoring serum phosphate and accepting nutritional treatment more than 3 days were included in our retrospective study. RFS was defined as the new onset hypophosphatemia (Results: A total of 1678 patients were included, of which 150(8.7%) were regularly monitored for serum phosphate. Among these 150 patients, 27 patients were diagnosed the RFS finally. Except for NRS 2002, there were no significant difference in nutritional index such as BMI, percentage of High-risk RFS, total caloric intake, baseline of potassium, magnesium, phosphate and calcium and time to start feeding among three groups. Also, there were no significant differences in clinical outcome, duration of mechanical ventilation and LOS of ICU and hospital. The NRS2002 scores of the three groups were 0.75±0.957, 3.00±1.541 and 4.50±1.049 respectively, and the higher the decline of serum phosphate, the higher the NRS2002 score was (P=0.001). Conclusions: The refeeding hypophosphatemia incidence was not rare in intensive care unit，even serum phosphate has not been monitored regularly. The higher score of NRS2002 might be correlated with greater decline of serum phosphate. However, changes in serum phosphate may be unrelated to prognosis and not be an optimal indicator of low calorie feeding.Trial registration: ClinicalTrials.gov database, NCT04005300. Registered 1 July 2019, https://clinicaltrials.gov/ct2/show/ NCT04005300 |
