No Association Between Human Immunodeficiency Virus Infections And Dementia: A Nationwide Cohort Study In Taiwan
| Autor: | Chuan-Chi Yang, Wan-Chun Lu, Kuang-Huei Chen, Yia-Ping Liu, Chi-Hsiang Chung, Wu-Chien Chien, Szu-Nian Yang, Yu-Chen Kao, Chin-Bin Yeh, Nian-Sheng Tzeng, Hsin-An Chang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Hazard ratio Human immunodeficiency virus (HIV) virus diseases medicine.disease medicine.disease_cause Confidence interval 030227 psychiatry 03 medical and health sciences 0302 clinical medicine National health insurance Internal medicine medicine Dementia Database research business 030217 neurology & neurosurgery Survival analysis Cohort study |
| Zdroj: | Neuropsychiatric Disease and Treatment. 15:3155-3166 |
| ISSN: | 1178-2021 |
| Popis: | Background The associations between the human immunodeficiency virus (HIV) and dementias are as yet to be studied in Taiwan. The aim of this study is to clarify as to whether HIV infections are associated with the risk of dementia. Methods A total of 1,261 HIV-infected patients and 3,783 controls (1:3) matched for age and sex were selected between January 1 and December 31, 2000 from Taiwan's National Health Insurance Research Database (NHIRD). Fine and Gray's survival analysis (competing with mortality) analyzed the risk of dementias during the 15-year follow up. The association between the highly active antiretroviral therapy (HAART) and dementia was analyzed by stratifying the HAART status among the HIV subjects. Results During the follow-up period, 25 in the HIV group (N= 1,261) and 227 in the control group (N= 3,783) developed dementia (656.25 vs 913.15 per 100,000 person-years). Fine and Gray's survival analysis revealed that the HIV patients were not associated with an increased risk of dementia, with the adjusted hazard ratio (HR) as 0.852 (95% confidence interval [CI]: 0.189-2.886, p=0.415) after adjusting for sex, age, comorbidities, geographical region, and the urbanization level of residence. There was no significant difference between the two groups of HIV-infected patients with or without HAART in the risk of dementia. Conclusion This study found that HIV infections, either with or without HAART, were not associated with increased diagnoses of neurodegenerative dementias in patients older than 50 in Taiwan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|