Stability of frozen solutions of cefazolin sodium

Autor:	Dennis L. Coleman, Patricia N. Thomas, James C. Boylan, Sandra M. Carone, Michael Bornstein
Rok vydání:	1976
Předmět:	Pharmacology Sodium bicarbonate Chromatography Health Policy Sodium Chloride Injection technology industry and agriculture equipment and supplies Diluent Median lethal dose Cefazolin Sodium chemistry.chemical_compound chemistry Anesthesia Potency hormones hormone substitutes and hormone antagonists
Zdroj:	American Journal of Health-System Pharmacy. 33:639-641
ISSN:	1535-2900 1079-2082
DOI:	10.1093/ajhp/33.7.639
Popis:	The stability of frozen solutions of cefazolin sodium was investigated in nine commonly used diluents at concentrations of 1 g with 2.5 ml, 500 mg with 100 ml and 10 g with 45 ml in both glass and polyvinylchloride plastic containers. The diluents were: Water for Injection USP; 0.9% Sodium Chloride Injection USP; 5% Dextrose Injection USP (D5W); D5W with 0.02% sodium bicarbonate; D5W in Lactated Ringer's Injection USP; Lactated Ringer's Injection USP; Ionosol B in D5W; Normasol M in D5W; and Plasmalyte in D5W. Frozen cefazolin sodium solutions, containing Water for Injection USP, 5% Dextrose Inection USP or 0.9% Sodium Chloride Injection USP as the diluents, retained more than 90% of labeled potency for up to 26 weeks when frozen within one hour after reconstitution and held at -10 C or -20 C. Frozen cefazolin sodium solutions, made with other diluents, were stable for up to four weeks when frozen within one hour after reconstitution and held at -10 C.
Databáze:	OpenAIRE
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