Mechanism of Action of Jatropha Gossypifolia Stem Latex As a Haemostatic Agent
| Autor: | Godwin Avwioro, T. Oduola, Ganiyu Adeosun, Mutiyat Adeyoola Oyeniyi, Tesleem Aderemi Oduola |
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| Rok vydání: | 2005 |
| Předmět: |
Dilution technique
Haemostatic agent Traditional medicine medicine.diagnostic_test Serial dilution biology business.industry General Medicine Jatropha gossypifolia Mechanism of action Bleeding time Botany medicine biology.protein Whole blood clotting time Bovine serum albumin medicine.symptom business |
| Zdroj: | Electronic Journal of General Medicine. 2:140-143 |
| ISSN: | 2516-3507 |
| DOI: | 10.29333/ejgm/82329 |
| Popis: | Aim: Jatropha gossypifolia belongs to the family “Euphorbiacea”. The coagulant activity and the mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent were investigated. Methods: The mechanism of action was investigated using doubling dilution technique by mixing neat (undiluted) and serial dilutions of the latex with 30% bovine albumin. Results: The results of whole blood clotting time using Lee and White method and bleeding time using Ivy’s method were significantly reduced (P < 0.05) when stem latex was introduced than when the tests were performed without stem latex. This means that the stem latex possesses procoagulant activity. Conclusion: The result of this test showed that precipitation of coagulant factors is the mechanism of action of its haemostatic activity. |
| Databáze: | OpenAIRE |
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