Pyrano[3,2-c]julolidin-2-ones: a novel class of fluorescent probes for ratiometric detection and imaging of Hg2+ in live cancer cells
| Autor: | Ajay Kumar Jha, Rakesh K. Arya, Atul Goel, Shahida Umar, Dipak Datta |
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| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Chemistry High selectivity Biomedical Engineering Analytical chemistry General Chemistry General Medicine 010402 general chemistry 01 natural sciences Combinatorial chemistry Fluorescence 0104 chemical sciences Contaminated water Test strips Intramolecular force Cancer cell General Materials Science |
| Zdroj: | Journal of Materials Chemistry B. 4:4934-4940 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/c6tb01413e |
| Popis: | A novel pyrano[3,2-c]julolidin-2-one based fluorescent molecular rotor PYJO4 has been designed and developed for selective ratiometric detection, quantification and imaging of intracellular Hg2+ in live cells. The probe operates via a Twisted Intramolecular Charge Transfer (TICT) mechanism and exhibits high selectivity and sensitivity up to 1.14 ppb. PYJO4 coated test strips can be used to detect mercury ions in contaminated water. |
| Databáze: | OpenAIRE |
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