Detection of red cell sensitisation by antibody and complement: Current practice and future perspectives

Autor: D. R. E. Jones
Rok vydání: 1993
Předmět:
Zdroj: Comparative Haematology International. 3:201-213
ISSN: 1618-565X
0938-7714
DOI: 10.1007/bf02341967
Popis: In autoimmune haemolytic anaemia (AHA) antibody(ies) are directed at ‘self’ red blood cells (RBC) and can effect their destruction. This removal of RBC may be enhanced by the additional presence of complement on the cell membrane. The diagnosis of AHA requires the demonstration of such antibody(ies), which are able to sensitise autologous erythrocytes in vivo. AHA has been described in a variety of animal species but the techniques employed in the laboratory diagnosis have, generally, been extrapolated from those used in human serology. The application of newer and more sensitive techniques to the assessment of RBC sensitisation with antibody and complement, has improved the diagnosis of AHA. Furthermore, it is now possible to assess the significance of the degree of RBC sensitisation and to evaluate treatment regimens. Approaches to the assessment of RBC sensitisation are: Rigorous controls are required to achieve reproducible results. With the regular use of such assay systems in clinical pathology and in toxicology screening, it will be necessary to consider a national quality control scheme.
Databáze: OpenAIRE
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