СУЧАСНИЙ СТАН СТВОРЕННЯ, ВИРОБНИЦТВА ТА ДОСЛІДЖЕННЯ ШВИДКОРОЗЧИННИХ ОРАЛЬНИХ ПЛІВОК
| Autor: | V Skorokhoda, T. A. Hroshovyi, M. B. Demchuk, Yu. Ya. Melnyk |
|---|---|
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Фармацевтичний часопис. |
| ISSN: | 2414-9926 2312-0967 |
| DOI: | 10.11603/2312-0967.2017.2.7907 |
| Popis: | The aim of the work. The literature data on the basic characteristics, features of technology, opportunities of use fast dissolving oral fiilms were studied and summarized. Materials and Methods. Literature review of dosage form-fast dissolving oral film. Results and Discussion. Fast dissolving oral fiilm is a very thin film with area of 5-20 cm 2 , which the patient can placed on the tongue or the mucous membrane in the mouth. Saliva, which wets the film, leads to rapid hydration and it adhesion to the place of use. Composition of fast dissolving oral films is consisting of active pharmaceutical ingredients, water-soluble polymers, plasticizers, sweeteners, flavors, saliva stimulating agents. The following processes can be used to manufacture the oral fast dissolving films: solvent casting method, semisolid casting, hot-melt extrusion method, rolling method. To evaluate the quality of films, mechanical properties, organoleptic characteristics, pH of film surface, transparency, uniformity of content, disintegration, dissolution, quantitative determination are determined. Conclusions. The main characteristics, technology, and the possibility of using films those are capable of attaching to the oral mucosa rapidly releasing drugs were considered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|