Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model
| Autor: | Dai Ling, Yang Zhen-jiang, Feng Yu-li, Zhao Xia, Zou Ying-zhen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry Angiogenesis Cancer General Medicine Blood stasis Matrix metalloproteinase Matrix (biology) medicine.disease biology.organism_classification Vascular endothelial growth factor chemistry.chemical_compound Nude mouse Complementary and alternative medicine Antigen chemistry medicine Pharmacology (medical) business |
| Zdroj: | Chinese Journal of Integrative Medicine. 10:127-130 |
| ISSN: | 1993-0402 1672-0415 |
| DOI: | 10.1007/bf02836385 |
| Popis: | Objective: To study the effect of Suiqing Pill (SQP), a TCM compound drug that can activate blood circulation and get rid of blood stasis, on angiogenesis in tumor and its possible mechanism.Method: BALB/c nude mice were inoculated with melanoma cell line B16 at right armpit subcutaneously to establish cancer spontaneous metastasis model. Levels of microvessel density (MVD), vascular endothelial growth factor (VEGF) and protein expression of matrix metalloproteinase-2 (MMP-2) in tumor tissues were observed and compared.Results: Strong expression of anti-Factor VIII (FVIII) related antigen and plentiful tumor angiogenesis were seen in model control animals, while in the high-dose and low-dose SQP treated model mice, MVD was inhibited by 33.5% and 22.6% respectively (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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