Hemodialysis Coil-induced Transient Neutropenia and Overshoot Neutrophilia in Normal Man
| Autor: | R.J. Nothum, Karl D. Nolph, Leonard H. Brubaker, Charles A. Johnson, Douglas P. Jensen |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
business.industry Lymphocyte medicine.medical_treatment Immunology Cell Biology Hematology Monocytopenia Neutropenia Phlebotomy medicine.disease Biochemistry Gastroenterology Neutrophilia Surgery medicine.anatomical_structure Internal medicine medicine Overshoot (microwave communication) Hemodialysis medicine.symptom business |
| Zdroj: | Blood. 41:399-408 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Profound transient neutropenia, followed by an overshoot of the neutrophil (N) count to an average of 2.5 ± 1.0 (mean ± 1 SD) times higher than average control N count, has been induced in seven normal subjects by reinfusion of heparinized blood that had been stagnated in a hemodialysis coil for 15 min. This was similar to the neutropenia-neutrophilia cycle occurring shortly after the initiation of hemodialysis in uremic patients. At the time of neutropenia, profound monocytopenia was also observed, but only a slight drop in lymphocyte count occurred. Neither monocytes nor lymphocytes subsequently recovered to higher than control values. A DF32P standard N survival procedure, performed in one subject with Hodgkin’s disease in complete unmaintained remission, showed that a large number of unlabeled N appeared during the overshoot, suggesting their marrow origin. Although in two of three attempts neutropenia was produced by reinfusion of blood through the coil without stagnation, no significant overshoot of N count following neutropenia occurred without the stagnation step. Simple phlebotomy and reinfusion of blood without the coil had no effect on the N count. This model may prove useful in studying the possible immediate regulation of the N count by marrow release of N and marrow N reserves in various patients. |
| Databáze: | OpenAIRE |
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