Ruthenium(II)-catalyzed N-substituted phthalimide synthesis via C–H activation/[3+2] annulation
| Autor: | Xian-Ying Shi, Xue-Fen Dong, Peng-Min Wang, Juan Fan, Junfa Wei, Ke-Yan Liu |
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| Rok vydání: | 2015 |
| Předmět: |
Annulation
Chemistry Organic Chemistry Intermolecular force chemistry.chemical_element Biochemistry Medicinal chemistry Catalysis Ruthenium Inorganic Chemistry Phthalimide chemistry.chemical_compound Intramolecular force Materials Chemistry Nucleophilic substitution Surface modification Physical and Theoretical Chemistry |
| Zdroj: | Journal of Organometallic Chemistry. 779:55-61 |
| ISSN: | 0022-328X |
| Popis: | Ruthenium-catalyzed intermolecular [3 + 2] annulation pathway for aromatic acids with isocyanates to afford N-substituted phthalimide in one step is demonstrated, which provides an efficient process to direct preparation of phthalimide from commercially available starting materials and environmentally benign catalysts. This cascade cyclization involves the direct functionalization of an ortho C–H bond and the subsequent intramolecular nucleophilic substitution. There is no theoretical waste except for water generated in the reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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