GABA is an inhibitory neurotransmitter in ganglia of the bivalve mollusc, Crassostrea virginica (1059.4)
| Autor: | Edward J. Catapane, Darlene Sylvain, Sadchla mathieu, Fatima Walden, Margaret A. Carroll |
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| Rok vydání: | 2014 |
| Předmět: |
0106 biological sciences
Beating rate animal structures biology Chemistry 010604 marine biology & hydrobiology Cilium 010501 environmental sciences Inhibitory neurotransmitter biology.organism_classification 01 natural sciences Biochemistry Cell biology Basal (phylogenetics) Genetics Excitatory postsynaptic potential Cerebral ganglion Crassostrea Serotonin Molecular Biology 0105 earth and related environmental sciences Biotechnology |
| Zdroj: | The FASEB Journal. 28 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.28.1_supplement.1059.4 |
| Popis: | In most studied bivalves, beating rate of gill lateral cilia is controlled by a reciprocal serotonergic-dopaminergic innervation from their cerebral ganglion (CG) and visceral ganglia (VG). GABA is a major inhibitory neurotransmitter in molluscs and other animals, but its actions have not been well studied in bivalves. We previously showed GABA inhibited actions of serotonin (HT) on increasing cilia beating when both were applied to the CG of C. virginica. We hypothesize GABA is also an inhibitory neurotransmitter in the VG of C. virginica and inhibits the excitatory HT neurons there as well. We tested this by examining effects of GABA at the VG. Cilia beating rates were measured by stroboscopic microscopy in animal preparations in which innervation of the gill by the CG was cut, but the innervation of the gill by the VG was left intact. Superfusing HT (10-6 - 10-3M) to the VG produced a dose-dependent increase in beating from an average basal rates of 10 beats/min to 25 beats/min. Superfusing GABA (10-6 ... |
| Databáze: | OpenAIRE |
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