EVALUATION OF INTERLEUKIN 6 POLYMORPHISMS AND ITS ASSOCIATION WITH RHEUMATOID ARTHRITIS IN BRAZILIAN WOMEN
| Autor: | Jair Carneiro Leão, Marília Lins E Silva, Luiz Alcino Monteiro Gueiros, Angela Luzia Branco Pinto Duarte, Alessandra De Albuquerque Tavares Carvalho, Camila Nunes Carvalho, Thayanara Silva Melo |
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| Rok vydání: | 2020 |
| Předmět: |
biology
business.industry medicine.disease Pathology and Forensic Medicine law.invention SNP genotyping law Genetic marker Rheumatoid arthritis Immunology Genotype biology.protein TaqMan Medicine Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Surgery Oral Surgery Allele Interleukin 6 business Polymerase chain reaction |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 129:e160 |
| ISSN: | 2212-4403 |
| Popis: | Objective To verify the association between serum interleukin 6 (IL-6) levels and IL-6 genetic polymorphisms in patients with rheumatoid arthritis (RA), as well as its association with disease activity and exocrine gland function. Methods. The study included 295 women, 173 had a diagnosis of RA and 122 were healthy. Clinical data and blood samples were collected. Serum IL-6 levels were measured by flow cytometry, and IL-6 genotypes were performed by real-time polymerase chain reaction (PCR) using TaqMan SNP genotyping assay. Results Patients in the RA group had higher levels of IL-6 (P Conclusions The presence of the C allele of IL-6 rs1800796 plays an important role in the pathogenesis of RA and, if confirmed in other populations, may be used as a genetic marker of the disease. |
| Databáze: | OpenAIRE |
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