Does the Pretransplant Use of Statins in Recipients Have a Role in the Incidence of Primary Graft Dysfunction after Lung Transplantation? R-ESTAcitos: Multicenter Clinical Study
| Autor: | Cristina Berastegui, Silvana Crowley, Alvaro Ballesteros, J. Escrivà, J. Galán, Alberto Jauregui, Judith Sacanell, A. Gómez, L. Sánchez, M. de la Torre, Elisabeth Coll, J. Perez, Candy Carranza Álvarez, Montserrat Diéguez Pérez, Víctor Manuel Mora, C. Mazo, M. Deu, Irene Bello, Alberto Sandiumenge, Fernando Mosteiro |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Transplantation medicine.medical_specialty Univariate analysis Statin biology business.industry medicine.drug_class medicine.medical_treatment Incidence (epidemiology) Primary Graft Dysfunction Organ transplantation Internal medicine Statistical significance HMG-CoA reductase biology.protein Medicine Lung transplantation lipids (amino acids peptides and proteins) Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Heart and Lung Transplantation. 39:S162 |
| ISSN: | 1053-2498 |
| DOI: | 10.1016/j.healun.2020.01.1113 |
| Popis: | Purpose Primary graft dysfunction (PGD) is the main cause of mortality during the first month and the second one within the first year after lung transplant (LT) Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, have shown to have immunomodulatory and antiinflamatory effects unrelated to their cholesterol-lowering function. We hypothesized that recipient's preoperative statin therapy is associated with decreased incidence of PGD after LT. Methods Multicenter retrospective analysis of all consecutive adult LTs performed in 5 university transplant centers between 2015 and 2017. Combined multiple organ transplantation and lung retransplant recipients were excluded from the analysis. Comparison between groups according to recipient previous use of statins(E+/E-)) was performed. Factors associated with the development of PGD and its severity were analyzed using Chisquare and U-Mann Whitney Test. Logistic regression model was built including those variables with p≤0.1 in the univariate analysis. Significance level p Results A total of 474 adult LT recipients were reviewed, 110 of them (E+=23%) were on statins treatment (SG). LT recipients in the statin group were older (60±7 vs 53±12; p Conclusion Statin use may contribute to lessen the severity of PGD. Prospective and multicentric studies with larger samples are needed to confirm such results. |
| Databáze: | OpenAIRE |
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