TRANSIENT ABNORMAL MYELOPOIESIS IN A NEONATE

Autor:	Chethan Manohar, Ketan P. Mallya, Sushma Belurkar, M Deepak Nayak
Rok vydání:	2013
Předmět:	Pathology medicine.medical_specialty Poor prognosis business.industry Transient abnormal myelopoiesis Metabolic acidosis Congenital leukemia medicine.disease Perinatal asphyxia hemic and lymphatic diseases Left shift medicine Pulmonary hemorrhage Myeloid leukaemia business
Zdroj:	Journal of Evolution of medical and Dental Sciences. 2:184-188
ISSN:	2278-4802 2278-4748
DOI:	10.14260/jemds/241
Popis:	Transient abnormal myelopoiesis (TAM) is a unique disorder of newborns associated intimately with Down’s syndrome, presenting with clinical and morphological features indistinguishable from acute myeloid leukaemia (AML). We report a case in a neonate, presenting with severe perinatal asphyxia and cyanosis; complicated by metabolic acidosis. The hemogram revealed leucocytosis and thrombocytopenia. The peripheral smear showed marked left shift and 55% circulating myeloblasts. Additional findings included a hepatomegaly and mild dysmorphic features. The child eventually succumbed to pulmonary hemorrhage on day one itself. TAM has to be differentiated from congenital leukemia which portends a poor prognosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::70ee7c44e315243e99136b1db16179c9 https://doi.org/10.14260/jemds/241 Zobrazit plný text záznamu