| Popis: |
The components of stroma (extracellular matrix (ECM), various connective tissue cells) play a leading role in epithelio-stromal relationships, the nature of which changes in dysplasia of connective tissue (DCT), reflected in numerous stigmas of dysmorphogenesis and the course of various types of pathology. Fibroblasts are among the most important cells of the stroma; they are responsible for self-renewal and remodeling of the ECM and have a powerful morphogenetic effect on tissues. In order to identify the features of the state of the subepithelial stroma, an analysis of clinical data and a morphological study (light microscopy and morphometry) of cervical biopsy specimens in background and precancerous processes in the presence (group 1) and absence (group 2) of concomitant DCT was carried out. The results of the study showed that statistically significant differences in the density of fibroblasts (by groups, respectively, Me=36.4; Q25=25.8; Q75=45.0 and Me=18.0; Q25=15.0; Q75=21.8; p=0.05) and relative surface area of vessels (by groups Me=8.0; Q25=4.5; Q75=10.1 and Me=3.1; Q25=1.7; Q75=4.9; p |
