Effect of synbiotic supplementation on asprosin level in high fat diet-induced metabolic disorder in pregnant rats
| Autor: | Hamed Fanaei, Farzaneh Montazerifar, Mehrdad Naghizadeh, Alireza Dashipour, Mansour Karajibani |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics business.industry Endocrinology Diabetes and Metabolism digestive oral and skin physiology Metabolic disorder food and beverages nutritional and metabolic diseases High fat diet medicine.disease Endocrinology Internal medicine Medicine lipids (amino acids peptides and proteins) business Food Science |
| Zdroj: | Mediterranean Journal of Nutrition and Metabolism. 15:81-90 |
| ISSN: | 1973-7998 1973-798X |
| DOI: | 10.3233/mnm-210595 |
| Popis: | Synbiotic supplementation can improve metabolic disorders. The aim of this study was to assess the impact of synbiotic supplementation on the levels of asprosin, lipid profile, glucose, and insulin resistance in pregnant rats fed a high-fat diet (HFD). Rats were divided into three groups: control group (fed base chow), HFD group, and HFD + synbiotic group. Levels of blood glucose, total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), insulin, and asprosin levels were measured. Birth weight of offspring in the HFD + synbiotic group was significantly lower than in the HFD group. Similarly, serum asprosin, insulin, insulin resistance, TG and total cholesterol levels in the HFD + symbiotic group were significantly lower than in the HFD group. Asprosin levels had a significant and positive correlation between food intake in the first ten days of the experiment and gestation period, fasting blood sugar (FBS), TG, and homeostatic model assessment (HOMA) index. Moreover, asprosin levels had a significant and negative correlation with HDL and insulin levels. Results showed, synbiotic supplementation has beneficial effects on obese animals and improves weight gain during pregnancy, pup birth weight, FBS, insulin resistance and lipid profile. These advantages of synbiotic supplementation could be mediated by reducing serum asprosin levels. |
| Databáze: | OpenAIRE |
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