| Autor: |
Wolfgang Zink, Daniel Wadsack, Michael Bovet, Florentina Kosely, Ralf Zahn |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-26470/v1 |
| Popis: |
A 59 year old male patient was admitted to our hospital diagnosed with COVID-19 associated pneumonia. Upfront treatment with hydroxychloroquine and azithromycin was started. Because of clinical deterioration with ARDS, circulatory shock and increased hyperinflammatory markers six days later, a cytokine storm rose to the top of differential diagnosis and off-label treatment with IL 6 receptor antagonist Tocilizumab was initiated. Subsequently we observed a dramatic rise of D-dimers indicating coagulopathy. Perimyocarditis with severe cardiac arrhythmia occurred after a second dose was administered. Later the patient died due to multi organ failure. Exacerbation of cytokine storm following treatment with Tocilizumab could not be ruled out, despite a hitherto unreported relationship with COVID-19. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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