The Value of a Prothrombin Complex Concentrate in the Coagulation Defect of Liver Disease

Autor:	Leon Poller, Dymock Iw, Jean M. Thomson, G. Green
Rok vydání:	1975
Předmět:	medicine.medical_specialty Liver disease Coagulation Chemistry Internal medicine medicine medicine.disease Gastroenterology Value (mathematics) Prothrombin complex concentrate medicine.drug
Zdroj:	Thrombosis and Haemostasis Vth Congress.
ISSN:	2567-689X
DOI:	10.1055/s-0039-1689519
Popis:	A prothrombin complex concentrate rich in factor VII has been used in the management of the clotting defect in thirteen patients with liver disease. Adequate correction of coagulation was achieved immediately after the infusion in all cases. Within four hours there was some deterioration and by twenty-four hours the results approximated to pre-infusion values. Liver biopsy procedures were performed without haemorrhagic complication in the immediate post-infusion period. There was no evidence of induced intravascular coagulation.Other prothrombin complex concentrates have proved disappointing both in their failure to correct the clotting defect and their production of DIC. From our results the use of this factor “VII rich concentrate appears to be the treatment of choice in patients with liver disease requiring temporary correction of the coagulation defect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::70c6e8b26f951d9f938e0774ecb0b5bc https://doi.org/10.1055/s-0039-1689519 Zobrazit plný text záznamu