Descending dopaminergic control of brainstem locomotor circuits
| Autor: | Alain Frigon, Maxime Fougère, Aurélie Flaive, Dimitri Ryczko |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
biology Physiology Pars compacta Lamprey fungi Dopaminergic hemic and immune systems chemical and pharmacologic phenomena Substantia nigra biology.organism_classification 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Physiology (medical) Basal ganglia medicine Zona incerta Brainstem Receptor Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Physiology. 8:30-35 |
| ISSN: | 2468-8673 |
| DOI: | 10.1016/j.cophys.2018.12.004 |
| Popis: | The locomotor role of meso-diencephalic dopaminergic (DA) neurons is traditionally associated with their ascending pathways to the basal ganglia, which project to the Mesencephalic Locomotor Region (MLR), a brainstem region controlling locomotion. However, descending DA projections to the MLR were recently reported in lamprey, where they promote locomotion through the activation of D1 receptors in the MLR. In rodents, the DA innervation of the MLR is conserved and originates from the substantia nigra pars compacta (A9) and medial zona incerta (A13). Intriguingly, the DA innervation of the MLR degenerates in a monkey model of Parkinson’s disease. Here, we review the current knowledge on these newly uncovered descending DA pathways to brainstem circuits and discuss their possible roles in locomotor control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect