Design, Fabrication, and Characterization of Novel Porous Conductive Scaffolds for Nerve Tissue Engineering
| Autor: | Mohammadhossein Dabaghi, Shohreh Mashayekhan, Marzieh Ramezani Farani, Ahmad Ramazani S.A, Fariba Ghaderinezhad, Hossein Baniasadi |
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| Rok vydání: | 2015 |
| Předmět: |
Nanocomposite
food.ingredient Materials science Polymers and Plastics Biocompatibility General Chemical Engineering Swelling capacity technology industry and agriculture Emulsion polymerization Polypyrrole Gelatin Analytical Chemistry Chitosan chemistry.chemical_compound food chemistry Tissue engineering Composite material |
| Zdroj: | International Journal of Polymeric Materials and Polymeric Biomaterials. 64:969-977 |
| ISSN: | 1563-535X 0091-4037 |
| DOI: | 10.1080/00914037.2015.1038817 |
| Popis: | Highly conductive polypyrrole/graphene (PYG) nanocomposite was synthesized with chemical oxidation process via emulsion polymerization and used for the preparation of novel porous conductive gelatin/chitosan-based scaffolds. The effect of PYG loading on various properties of scaffolds was investigated. The obtained results indicated that by introducing PYG into the polymeric matrix, the porosity and swelling capacity decreased while electrical conductivity and Young's modulus demonstrated increasing trend. The in vitro biodegradation test revealed that pure gelatin/chitosan matrix lost 80% of its weight after six weeks in the presence of lysozyme whilst the biodegradation rate was significantly lower for the conductive scaffolds. Furthermore, Schwann cell attachment and proliferation were evaluated by MTT assay and SEM image and the results revealed significant cell biocompatibility of the conductive scaffold with low amount of PYG. The results confirmed the potential of gelatin/chitosan/PYG compounding a... |
| Databáze: | OpenAIRE |
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