Cytokine Imbalance as a Biomarker of Intervertebral Disk Degeneration

Autor:	Natalia A. Shnayder, Azamat V. Ashhotov, Vera V. Trefilova, Zaitun A. Nurgaliev, Maxim A. Novitsky, Elena E. Vaiman, Marina M. Petrova, Regina F. Nasyrova
Rok vydání:	2023
Předmět:	Inorganic Chemistry Organic Chemistry General Medicine Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications
Zdroj:	International Journal of Molecular Sciences. 24:2360
ISSN:	1422-0067
Popis:	The intervertebral disk degeneration (IDD) and its associated conditions are an important problem in modern medicine. The onset of IDD may be in childhood and adolescence in patients with a genetic predisposition. IDD progresses with age, leading to spondylosis, spondylarthrosis, intervertebral disk herniation, and spinal stenosis. The purpose of this review is an attempt to summarize the data characterizing the patterns of production of pro-inflammatory and anti-inflammatory cytokines in IDD and to appreciate the prognostic value of cytokine imbalance as its biomarker. This narrative review demonstrates that the problem of evaluating the contribution of pro-inflammatory and anti-inflammatory cytokines to the maintenance or alteration of cytokine balance may be a new key to unlocking the mystery of IDD development and new therapeutic strategies for the treatment of IDD in the setting of acute and chronic inflammation. The presented data support the hypothesis that cytokine imbalance is one of the most important biomarkers of IDD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::70c0684010e1085e67da4df5ef0f9f95 https://doi.org/10.3390/ijms24032360 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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