| Autor: |
Harumi Hatano, Masao Kobayashi, Hiroyuki Yoshino, Masakazu Mizobe, Takashi Ishibashi |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutics. 168:31-40 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/s0378-5173(98)00082-9 |
| Popis: |
A new capsule-type dosage form was investigated for colon-targeted delivery of drugs. The system was designed by imparting a timed-release function and a pH-sensing function to a hard gelatin capsule. The technical characteristics of the system are to contain an organic acid together with an active ingredient in a capsule coated with a three-layered film consisting of an acid-soluble polymer, a water-soluble polymer, and an enteric polymer. In order to find the suitable formulation, various formulation factors were investigated through a series of in vitro dissolution studies. As a result, it was found that: (1) various organic acids can be used for this system; (2) a predictable timed-release mechanism of a drug can be attained by adjusting the thickness of the Eudragit®E layer; and (3) the outer enteric coating with HPMC®-AS provided acceptable acid-resistibility. All these results suggested that this approach can provide a useful and practical means for colon-targeted delivery of drugs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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