The Safety and Efficacy of Topical Norfloxacin Compared with Placebo in the Treatment of Acute, Bacterial Conjunctivitis
| Autor: | Ian Miller, Roger Vogel, Cook Tj, J M Wittreich |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Bacterial Conjunctivitis
medicine.medical_specialty Chemotherapy business.industry medicine.drug_class Eye disease medicine.medical_treatment Antibiotics Acute Conjunctivitis Eye drop General Medicine medicine.disease Placebo Surgery 03 medical and health sciences Ophthalmology 0302 clinical medicine Internal medicine parasitic diseases 030221 ophthalmology & optometry Medicine business 030217 neurology & neurosurgery Norfloxacin medicine.drug |
| Zdroj: | European Journal of Ophthalmology. 2:58-66 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/112067219200200202 |
| Popis: | Two hundred and eighty-four patients with acute conjunctivitis were enrolled in a double-masked study comparing norfloxacin ophthalmic solution with placebo. The proportion of patients who were clinically improved after 5 days treatment was 88.1% in the norfloxacin group and 71.6% in the placebo group (p less than 0.01). The proportion of patients who had all organisms eradicated, including the coagulase-negative staphylococci, after two to three days treatment was 52.7% for norfloxacin and 23.9% for placebo (p less than 0.01) and 64.7% and 26.3% (p less than 0.01) respectively when the coagulase-negative staphylococci were not included. Adverse experiences occurred in 4.2% of the patients receiving norfloxacin compared to 7.1% of the placebo patients. None of the adverse experiences was serious. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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