Comparison of enantioselective reductions using bead and monolith ‘disk’ polymer formulations of CBS catalysts
| Autor: | Saori Shiraki, Michael D. Price, Michael C. Varela, Neil E. Schore, Mark J. Kurth, Patrick E. Berget, Seth Dixon, Jeffrey E. Merit |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
geography Ketone geography.geographical_feature_category Organic Chemistry Enantioselective synthesis Polymer Bead Biochemistry Catalysis chemistry.chemical_compound chemistry visual_art Drug Discovery visual_art.visual_art_medium Organic chemistry Monolith CBS catalyst |
| Zdroj: | Tetrahedron. 63:3334-3339 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2007.02.048 |
| Popis: | Two polymer-supported versions of the Corey, Bakshi, and Shibata (CBS) catalyst were prepared and examined. Polymeric beads, with the auxiliary bound in pendant and crosslinked fashion, were prepared utilizing an improved procedure based upon earlier work. Optimization of a procedure for ketone reduction gives results that match those in solution. Attempted reuse gave mixed results. For comparison purposes, CBS functionalized monoliths were formed and tested but performed poorly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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