| Popis: |
Plasma cell neoplasms are interrelated by the finding of an expanded monoclonal plasma cell population. The degree of bone marrow involvement, the type and quantity of secreted monoclonal immunoglobulin (M protein), and associated laboratory, radiographic, and clinical findings help to classify these disorders into several entities: Monoclonal gammopathy of undetermined significance (MGUS) Solitary plasmacytoma Plasma cell myeloma (PCM) Monoclonal immunoglobulin deposition diseases The basic genetic events that lead to plasma cell oncogenesis are similar in the different plasma cell neoplasms. Underlying genetic variations likely explain the heterogeneous clinical behavior in patients with these different disorders. |
