| Popis: |
Pharmacokinetics of large molecules, such as rG-CSF and erythropoietin after subcutaneous administration, was discussed based mainly upon the observations of kinetics of rG-CSF and other molecules. The mean absorption time (MAT) and the variance of absorption time (VAT) of rG-CSF were calculated, and the ratio of VAT/(MAT)2 was less than 1, suggesting that the absorption process might be catenary process. The absorption processes of large molecules might consist of molecule independent and dependent processes. The kinetics of erythropoietin suggested that the injection volume might contribute to the molecule independent process. |
