Metabolites from Excoecaria cochinchinensis Lour
| Autor: | Lai Hop Hieu, Nguyen Phuong Thao, Do Hoang Anh, Tran Thi Hong Hanh, Nguyen Duy Cong, Nguyen The Cuong, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Ngo Dai Quang, Chau Van Minh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
biology
Lipopolysaccharide 010405 organic chemistry Stereochemistry Positive control Plant Science biology.organism_classification 01 natural sciences Biochemistry Terpenoid 0104 chemical sciences Nitric oxide Excoecaria cochinchinensis 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry No production Agronomy and Crop Science IC50 Derivative (chemistry) Biotechnology |
| Zdroj: | Phytochemistry Letters. 37:116-120 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2019.08.003 |
| Popis: | A new rhamnofolane-type diterpenoid (1) and a new phenolic derivative (2), together with eleven known compounds, were isolated from the leaves of E. cochinchinensis Lour. The chemical structures of these compounds were elucidated based on extensive spectroscopic analysis, including HR-QTOF-MS and NMR, and comparison with reported data. The inhibitory effects of compounds 1–13 on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. As the obtained results, compound 9 showed a moderate inhibitory effects on NO production activity with an IC50 of 6.17 ± 0.25 µM, relative to that of the positive control cardamonin. |
| Databáze: | OpenAIRE |
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