Anti-inflammatory and analgesic activity of 5-aryl-4-acyl-1-heteryl-3-hydroxy-3-pyrrolin-2-ones

Autor:	K. V. Yatsenko, V. L. Gein, L. F. Gein, T. A. Splina, S. G. Shevtsova, V. V. Yushkov
Rok vydání:	2008
Předmět:	Pharmacology medicine.drug_class Stereochemistry Aryl Analgesic Substituent Pyrroline Ring (chemistry) Anti-inflammatory chemistry.chemical_compound chemistry Drug Discovery medicine Inflammatory edema Acetylpyruvic acid
Zdroj:	Pharmaceutical Chemistry Journal. 42:255-257
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-008-0100-3
Popis:	A three-component reaction of acetylpyruvic acid esters, aromatic aldehydes, and heterylamines was used to synthesize 3-hydroxy-3-pyrrolin-2-ones containing heterocyclic substituents at the 1 position of the pyrroline ring. The effects of the heterocyclic substituent on the extent of anti-inflammatory and analgesic actions were studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7091a15e623c5a9ef98edea2958ee9b5 https://doi.org/10.1007/s11094-008-0100-3 Zobrazit plný text záznamu Plný text ve formátu PDF