Investigations and Modeling of the Effect of Magnetic Nanoparticles on MR Image Contrast
| Autor: | Yu. V. Bogachev, Ya. Yu. Marchenko, A. V. Nikitina, B. P. Nikolaev |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
medicine.diagnostic_test Pulse (signal processing) Contrast effect Relaxation (NMR) Nanoparticle Magnetic resonance imaging equipment and supplies 010402 general chemistry 01 natural sciences Atomic and Molecular Physics and Optics Imaging phantom 030218 nuclear medicine & medical imaging 0104 chemical sciences 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance medicine Magnetic nanoparticles Tomography human activities |
| Zdroj: | Applied Magnetic Resonance. 51:117-127 |
| ISSN: | 1613-7507 0937-9347 |
| DOI: | 10.1007/s00723-019-01179-9 |
| Popis: | The investigations of nuclear magnetic resonance (NMR) relaxation of protons in aqueous solution and 2% agar–agar gel in the presence of magnetic nanoparticles were performed. To identify the effect of magnetic nanoparticles on the contrast of magnetic resonance images, the dependences of the MR signal intensity on the parameters of the two pulse radio-frequency (RF) sequences (spin-echo, gradient-echo) most commonly used in MRI for different values of the magnetic nanoparticle (MNP) concentration were simulated and analyzed. Recommendations for choosing the optimal values of pulse RF sequence parameters for MR imaging (MRI) in the presence of MNPs are formulated. MRI studies of phantom samples with 2% agar–agar gel containing MNPs have been performed for choosing the fast pulse RF sequence which shows the greatest contrast effect on MR images. A program for modeling magnetic resonance tomograms and determination of optimal values of pulse RF sequence parameters to achieve the best contrast of magnetic resonance images is developed. This program allows to reduce the time of MRI studies, to assess the possibility of using MNPs for contrast of MR images and to simulate the MR image in the presence of magnetic nanoparticles at the planning stage of procedures in MR-guided theranostics. |
| Databáze: | OpenAIRE |
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