Selective Sensing of Peroxynitrite by Hf-Based UiO-66-B(OH)2 Metal–Organic Framework: Applicability to Cell Imaging
| Autor: | Vishal Trivedi, Mostakim Sk, Shyam Biswas, Rakesh Kumar Singh, Soutick Nandi |
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| Rok vydání: | 2018 |
| Předmět: |
inorganic chemicals
Detection limit Ligand Formic acid 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Fluorescence 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound chemistry Extracellular Metal-organic framework Physical and Theoretical Chemistry 0210 nano-technology Peroxynitrite Boronic acid Nuclear chemistry |
| Zdroj: | Inorganic Chemistry. 57:10128-10136 |
| ISSN: | 1520-510X 0020-1669 |
| Popis: | The first boronic acid functionalized Hf-based UiO-66 (UiO = University of Oslo) metal–organic framework (MOF) having the ability to detect both extracellular and intracellular peroxynitrite is presented. The Hf-UiO-66-B(OH)2 material (1) was synthesized under solvothermal conditions from a mixture of HfCl4 and 2-borono-1,4-benzenedicarboxylic acid [H2BDC–B(OH)2] ligand in DMF in the presence of formic acid (modulator) at 130 °C for 48 h. The desolvated material (1′) was utilized as a fluorescent turn-on probe for the rapid sensing of extracellular peroxynitrite (ONOO–) under conditions mimicking those of biological medium (10 mM HEPES buffer, pH 7.4). Selective sensing of ONOO– over other ROS/RNS was also achieved by 1′. The oxidative cleavage of attached boronic acid groups forming corresponding hydroxy-functionalized ligands can be accounted for the fluorescent increment phenomenon in the presence of ONOO–. The probe showed extraordinary sensitivity (detection limit = 9.0 nM) toward ONOO– in 10 mM HEPE... |
| Databáze: | OpenAIRE |
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