Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis
| Autor: | Chao-Jiang Xiao, Xiao-Nian Li, Yan-Chun Liu, Lin-Lin Teng, Sheng-Hong Li, Fang Zeng, Jian-Xiong Gao, De-Sen Li, Yan Liu, Rong-Fang Mu, Kai Guo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Chemistry Stereochemistry medicine.medical_treatment Organic Chemistry Diastereomer Ether 010402 general chemistry Inhibitory postsynaptic potential 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Cytokine Adipogenesis medicine Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 23:2232-2237 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.1c00369 |
| Popis: | Eurysoloids A (1) and B (2), two novel diastereomeric sesterterpenoids possessing a pentacyclic 5/6/5/10/5 framework with an unusual macrocyclic ether system, were isolated from Eurysolen gracilis Prain. Their structures were unambiguously determined by spectroscopic, single-crystal X-ray diffraction and DP4+ analyses. A plausible biosynthetic pathway for compounds 1 and 2 was proposed. Both compounds exhibited immunosuppressive activity via inhibiting the production of cytokine IFN-γ of T cells, and compound 2 inhibited adipogenesis in 3T3-L1 adipocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|