Methyl Donors Supplementation Attenuates the Adverse Effects of Maternal High Fructose Diet of Offspring Emotional and Cognitive Behaviors
| Autor: | Amina El Hasnaoui, Abdeljabbar Nassiri, Sidi Mohamed Coulibaly, Abdelhalem Mesfioui, Pacôme Kouadio N’Go, Aboubaker El Hessni, Ali Ouichou |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pregnancy Offspring business.industry 030209 endocrinology & metabolism Fructose medicine.disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure Endocrinology chemistry In utero Internal medicine Lactation medicine Gestation Juvenile Adverse effect business 030217 neurology & neurosurgery |
| Zdroj: | Open Journal of Endocrine and Metabolic Diseases. :203-218 |
| ISSN: | 2165-7432 2165-7424 |
| DOI: | 10.4236/ojemd.2017.711018 |
| Popis: | Free Fatty acid is an end-product of hepatic metabolism of fructose. Most of past studies have demonstrated significant relationship between gestational high fat diet and metabolic and physiology outcomes in offspring. However, there is a scarce of data extended to the effects of high fructose diet-fed dams on juveniles’ progeny. Therefore, the present experiment was designed to examine the later effects of maternal high fructose diet intake during pregnancy and lactation on juvenile offspring rats emotional behaviors and memory abilities. We tested whether methyl donors supplemented to that high fructose diet could reverse the adverse effects. We found at two months of age, anxiety-like behavior and depression-like behavior were elevated in off springs of mother fed to high fructose diet and a sex difference effect with males were more affected than females. In addition, behavioral outcomes indicated that the high fructose diet also impaired spatial working and recognition memories in the Y-maze and object recognition test respectively. Blood glucose intolerance increased significantly in juvenile males rats of dams fed with high fructose diet when compared to females. However, a supplementation of the maternal diet with methyl donors attenuated all these changes. Our study suggested a controlled fructose diet supplemented to methyl donors during critical period of brain developing (in utero and pre-weaning stage), otherwise that could induced irreversible detrimental effects on offspring behavior and cognitive health. |
| Databáze: | OpenAIRE |
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