Insights into the mechanism of Cymbopogan martinii essential oil in topical therapy of acne vulgaris
Autor: | Sheefali Mahant, Nikhil Shri Sahajpal, Sanju Nanda |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Future Microbiology. 16:1181-1193 |
ISSN: | 1746-0921 1746-0913 |
Popis: | Aim: The present study investigated the essential oil of Cymbopogan martinii (palmarosa oil; PRO) as a potential topical therapy in acne vulgaris. Materials & methods: GC-MS profiling and biocompatibility studies of PRO were undertaken. The antimicrobial potential was assessed against Cutibacterium acnes. anti-inflammatory, antityrosinase activity and lipid peroxidation were also evaluated. Results: Geraniol was identified as the major phytoconstituent, and the oil was found to be safe for topical application. The minimum inhibitory concentration and minimum bactericidal concentration values were noted as 16 μl/ml. PRO reduced the cytokine levels of TNF-α, IL-12 and IL-8 and inhibited tyrosinase. A low concentration of the oil (up to 0.5 μl/ml) produced malondialdehyde levels equivalent to that of untreated cells. Conclusion: PRO may prove useful as a natural topical agent in the management of acne. |
Databáze: | OpenAIRE |
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