Regioselective Ortho Amination of an Aromatic C–H Bond by Trifluoroacetic Acid via Electrochemistry
| Autor: | Hao-Lin Wu, Tao Lei, Xiao-Lei Nan, Jing-Hao Wang, Bin Chen, Chen-Ho Tung, Xu-Bing Li, Li-Zhu Wu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Regioselectivity 010402 general chemistry Electrochemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Metal chemistry.chemical_compound chemistry Reagent visual_art visual_art.visual_art_medium Trifluoroacetic acid Alkoxy group Organic synthesis Physical and Theoretical Chemistry Amination |
| Zdroj: | Organic Letters. 21:5581-5585 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.9b01910 |
| Popis: | A trifluoroacetic acid-facilitated ortho amination of alkoxyl arene has been established via anodic oxidation in an undivided cell. In the absence of any additional metal or oxidant reagents, a series of aromatic and heteroaromatic amine derivatives have been synthesized in good to excellent yields. Our findings reveal the possibility of achieving complete ortho-selective amination of a simple arene, which emerges as an efficient route for facile and large-scale organic synthesis. |
| Databáze: | OpenAIRE |
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