Preparation of indole-phosphine oxazoline (IndPHOX) ligands and their application in allylic alkylation

Autor:	Yu Wang, Jan Tois, Robert Franzén, Antti Hämäläinen
Rok vydání:	2010
Předmět:	Indole test Chemistry Organic Chemistry Oxazoline Ring (chemistry) Dimethyl malonate Combinatorial chemistry Catalysis Inorganic Chemistry chemistry.chemical_compound Tsuji–Trost reaction Organic chemistry Moiety Physical and Theoretical Chemistry Phosphine
Zdroj:	Tetrahedron: Asymmetry. 21:2376-2384
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2010.08.008
Popis:	Two classes of indole-phosphine oxazoline ligands have been prepared from readily available starting materials in good overall yields. These modular ligands include an indole skeleton with either a phosphine moiety or an oxazoline ring at the 2- or 3-position, respectively. The utility of these ligands was demonstrated in a catalytic asymmetric reaction: the palladium-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate was performed with enantioselectivities as high as 98%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::70508baefe67848274076fc71850e23b https://doi.org/10.1016/j.tetasy.2010.08.008 Zobrazit plný text záznamu Full Text from ScienceDirect