Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia
| Autor: | Christina W. Hoven, Fang Fan, Yuechu Zhang, Xianchen Liu, Ya Zhou, Daoming Wang, Lawrence Amsel, Min Jiang, Yuanyuan Li, Huilan Tang, Bin Zhang, Lin Li, Tong Wang |
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| Rok vydání: | 2020 |
| Předmět: |
biology
business.industry Inflammation Gut flora biology.organism_classification digestive system Sleep in non-human animals Proinflammatory cytokine 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine 030228 respiratory system mental disorders Immunology Insomnia Medicine Microbiome medicine.symptom Bacteroides business 030217 neurology & neurosurgery Applied Psychology Psychopathology |
| Zdroj: | Nature and Science of Sleep. 12:895-905 |
| ISSN: | 1179-1608 |
| DOI: | 10.2147/nss.s271927 |
| Popis: | Purpose The major purpose of this study was to detect the changes in gut microbiota composition and inflammatory cytokines production associated with acute and chronic insomnia. This study also evaluated the relationship between gut microbiota changes and increased inflammatory cytokines in insomnia patients. Patients and methods Outpatients with acute and chronic insomnia (aged 26-55 years; n=20 and 38, respectively) and age/gender-matched healthy controls (n=38) were recruited from a southern China region. Participants' gut microbiome, plasma cytokines, and self-reported sleep quality and psychopathological symptoms were measured. Results The gut microbiomes of insomnia patients compared with healthy controls were characterized by lower microbial richness and diversity, depletion of anaerobes, and short-chain fatty acid (SCFA)-producing bacteria, and an expansion of potential pathobionts. Lachnospira and Bacteroides were signature bacteria for distinguishing acute insomnia patients from healthy controls, while Faecalibacterium and Blautia were signature bacteria for distinguishing chronic insomnia patients from healthy controls. Acute/chronic insomnia-related signature bacteria also showed correlations with these patients' self-reported sleep quality and plasma IL-1β. Conclusion These findings suggest that insomnia symptomology, gut microbiota, and inflammation may be interrelated in complex ways. Gut microbiota may serve as an important indicator for auxiliary diagnosis of insomnia and provide possible new therapeutic targets in the field of sleep disorders. |
| Databáze: | OpenAIRE |
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