Indium/Fe(iii) – mediated regioselective β-cross-coupling aldol type addition reaction of activated alkenes with isatins/isatinimines in aqueous media

Autor:	A. Sanjeeva Kumar, Harshadas M. Meshram, G. Santosh Kumar, T. Prabhakar Rao, Palakuri Ramesh, Jagadeesh Babu Nanubolu
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Addition reaction General Chemical Engineering Isatin chemistry.chemical_element Substrate (chemistry) Regioselectivity General Chemistry Medicinal chemistry Coupling (electronics) chemistry.chemical_compound chemistry Aldol reaction Organic chemistry Indium Alkyl
Zdroj:	RSC Advances. 5:51581-51585
ISSN:	2046-2069
Popis:	A highly efficient and regioselective β-cross coupling aldol type addition reaction of activated alkenes with isatin/isatinimine derivatives in the presence of Indium/Fe(III) in THF/H2O at room temperature is described. Our synthetic protocol explores a broad substrate scope and smoothly proceeds under base-free conditions. The resulting products are obtained in a short reaction time with moderate to high yields. This is the first example of Mannich-type coupling of isatinimines with activated alkenes to afford the alkyl 3-(2-oxo-3-(phenylamino)indolin-3-yl)propanoates and 3-(3-oxoalkyl)-3-(phenylamino)indolin-2-ones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::70472dc825c72a69ab9ae2f5fe7f9e05 https://doi.org/10.1039/c5ra07216f Zobrazit plný text záznamu