OCT Signs of Early Atrophy in Age-Related Macular Degeneration: Interreader Agreement
| Autor: | Barbara A Blodi, John Choong, Amitha Domalpally, Sarah Thiele, Petrus Chang, Elvira Bjelopera, Muneeswar Gupta Nittala, Srinivas R. Sadda, Cindy Skalak, Zhichao Wu, Robyn H. Guymer, Tyler Brown, Federico Corvi, Giovanni Staurenghi, Steffen Schmitz-Valckenberg, Giulia Corradetti, Cynthia Hurtenbach, Glenn J. Jaffe, Maximilian Pfau, Marlene Saßmannshausen, Jeong W Pak, Sandra Liakopoulos, Anthony Olson, Frank G. Holz, Judith Pappe |
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| Rok vydání: | 2022 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Retinal pigment epithelium business.industry Outer plexiform layer Exploratory analysis Macular degeneration medicine.disease eye diseases Retinal atrophy 03 medical and health sciences Ophthalmology 0302 clinical medicine medicine.anatomical_structure Atrophy Age related 030221 ophthalmology & optometry Medicine sense organs business Spatial extent 030304 developmental biology |
| Zdroj: | Ophthalmology Retina. 6:4-14 |
| ISSN: | 2468-6530 |
| DOI: | 10.1016/j.oret.2021.03.008 |
| Popis: | PURPOSE: To determine the interreader agreement for incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA) and their related features in age-related macular degeneration (AMD). DESIGN: Interreader agreement study. PARTICIPANTS: Twelve readers from 6 reading centers. METHODS: After formal training, readers qualitatively assessed 60 OCT B-scans from 60 eyes with AMD for 9 individual features associated with early atrophy and performed 7 different annotations to quantify the spatial extent of OCT features within regions of interest. The qualitative and quantitative features were used to derive the presence of iRORA and cRORA and also in an exploratory analysis to examine if agreement could be improved using different combinations of features to define OCT atrophy. MAIN OUTCOME MEASURES: Interreader agreement based on Gwet's first-order agreement coefficient (AC1) for qualitatively graded OCT features and classification of iRORA and cRORA, and smallest real difference (SRD) for quantitatively graded OCT features. RESULTS: Substantial or better interreader agreement was observed for all qualitatively graded OCT features associated with atrophy (AC1 = 0.63-0.87), except for RPE attenuation (AC1 = 0.46) and disruption (AC1 = 0.26). The lowest SRD for the quantitatively graded horizontal features was observed for the zone of choroidal hypertransmission (± 190.8 μm). Moderate agreement was found for a 3-category classification of no atrophy, iRORA, and cRORA (AC1 = 0.53). Exploratory analyses suggested a significantly higher level of agreement for a 3-category classification using (1) no atrophy; (2) presence of inner nuclear layer and outer plexiform layer subsidence, or a hyporeflective wedge-shaped band, as a less severe atrophic grade; and (3) the latter plus an additional requirement of choroidal hypertransmission of 250 μm or more for a more severe atrophic grade (AC1 = 0.68; P = 0.013). CONCLUSIONS: Assessment of iRORA and cRORA, and most of their associated features, can be performed relatively consistently and robustly. A refined combination of features to define early atrophy could further improve interreader agreement. |
| Databáze: | OpenAIRE |
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