Human Chorionic Gonadotropin as a Model for a Fetal Antigen

Autor:	K. D. Bagshawe
Rok vydání:	2008
Předmět:	Pregnancy test endocrine system education.field_of_study biology business.industry Population Choriocarcinoma Cancer medicine.disease Human chorionic gonadotropin Antigen Immunization Immunology biology.protein Medicine Antibody business education
Zdroj:	Ciba Foundation Symposium 96-Fetal Antigens and Cancer ISBN: 9780470720776 Ciba Foundation Symposium 96-Fetal Antigens and Cancer
DOI:	10.1002/9780470720776.ch9
Popis:	Human chorionic gonadotropin (hCG) has an important biological function and has clinical use as a hormone, yet its applications as an antigen are also numerous. Pregnancy tests have brought immunological reactions into the high street pharmacy and the home. As a secreted antigen hCG provides for choriocarcinoma of gestational or germ cell origin our closest approximation to the ideal tumour marker. It is unique in providing the basis of a biochemical screening test for a specific cancer in a high risk population. It has a valuable role in diagnosis and prognosis and in monitoring this disease and detecting tumours is unknown. It has been investigated as a target for radioimmunolocalization studies with 131I-labelled anti-hCG antibodies, and found useful in some patients. Attempts have been made to improve the technique using liposomes containing a second antibody. As a target for antibody therapy in fertility control and oncology, by active or passive immunization methods, much depends on whether hCG functions as a cell membrane antigen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7020ef261bec2dffd67a44c21504c5c3 https://doi.org/10.1002/9780470720776.ch9 Zobrazit plný text záznamu