Influences of food matrices on cytotoxicity of asiatic acid in mammalian cell models

Autor:	Nuananong Jirakanjanakit, La-ongdao Wongekalak, Parichat Hongsprabhas, Kalyanee Jirasripongpun, Premwadee Sakulsom
Rok vydání:	2012
Předmět:	Hepatoblastoma medicine.disease digestive system diseases Industrial and Manufacturing Engineering Hydrolysate chemistry.chemical_compound chemistry Biochemistry ASIATIC ACID Apoptosis medicine Vero cell Lactose Cytotoxicity IC50 Food Science
Zdroj:	International Journal of Food Science & Technology. 47:1970-1976
ISSN:	0950-5423
DOI:	10.1111/j.1365-2621.2012.03058.x
Popis:	Summary This study investigated the cytotoxicity of asiatic acid (AA) encapsulated in different protein-carbohydrate matrices in human colon adenocarcinoma SW620, human hepatoblastoma HepG2 and diploid monkey kidney cells (Vero). Mungbean protein concentrate (MPC) and mungbean protein hydrolysate (MPH) in lactose (L) or lactose-maltodextrin (LM) mixture, were used to fabricate matrices encapsulating AA during lyophilisation. The cytotoxicity of AA was in a dose-dependent manner for HepG2 and SW620 cells, but not for Vero cells. The 50% inhibitory concentrations (IC50) of AA in HepG2 and SW620 were 120 and 130 μm respectively. The IC50 of AA encapsulated in MPH-L matrix in HepG2 was reduced from that of AA alone to 80 μm (P
Databáze:	OpenAIRE
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