Cholesterol level in peripheral blood lymphocytes: Relationship with ischemic heart disease in patients with various forms of hyperlipidemia
| Autor: | V.S. Repin, E. Yu. Solov'eva, Koshechkin Va, I. V. Fuki, Bolkhova La |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Chemistry Cholesterol Population General Medicine Disease medicine.disease General Biochemistry Genetics and Molecular Biology Peripheral blood chemistry.chemical_compound Endocrinology Internal medicine Hyperlipidemia Mole medicine Cardiology In patient education Ischemic heart |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 116:1349-1352 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00805142 |
| Popis: | Even though a correlation between the incidence of ischemic heart disease(IHD) and the plasma level of "atherogenic" cholesterol has been demostrated in a number of extensive population studies [1-3], the mechanism underlying this phenomenon remains unclear. It is generally accepted that a rise of plasma cholesterol (Ch) level above 6.5 mmol/ l i ter increases the risk of atherosclerotic plaque formation [4]. Cholesterol accumulation in the vascular intima is due to the transformation of macrophages and smooth muscle cells into foam cells [5,6], which does not reflect the Ch content of other cells in the body. Cholesterol accumulat ion in tissues may occur without pronounced hypercholesterolemia. Yu. M. Lopukhin has described "cholesterosis" of red blood cells in patients with hypercholesterolemia [7]. However, these non-nucleated cells do not have their system for own controlling Ch balance, and the Ch concentration in their plasma membrane simply reflects the intensity of the concentration gradient transport. The mechanism responsible for the coupling |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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