Immediate and Prolonged Effects of Drugs on Rhythm's Characteristics: Relevance to Chronochemotherapy

Autor:	Yona Y. Kitay-Cohen, R. Carlebach, Israel E. Ashkenazi, Alexander A. Zvulunov, Leah Peleg
Rok vydání:	1998
Předmět:	Daily pattern Vincristine Physiology business.industry Drug administration Wbc count Rhythm Physiology (medical) Anesthesia Medicine Time dependency business Ecology Evolution Behavior and Systematics medicine.drug
Zdroj:	Biological Rhythm Research. 29:286-292
ISSN:	1744-4179 0929-1016
DOI:	10.1076/brhm.29.3.286.1439
Popis:	Four groups of mice were injected with vincristine, each at a different time, for ten successive days. Mortality and daily pattern of peripheral white blood cells (WBC) count were monitored immediately and at various times after the last injection. The results demonstrated that (1) drug administration time dependency was observed in rate of death, recorded for 80 days following the injections; (2) the time of drug administration affected the parameters of WBC count rhythm, and (3) there were differences between immediate effects upon the rhythm parameters (monitored one day after the last injection) to those measured at succeeding times (on days 8 and 15 after injections cessation). The results emphasize the need to consider continuous post administration rhythm changes, especially when scheduling repeated chronotherapeutics, where variables which serve for toxicity-diagnosis are rhythmic in nature.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::700a3fe02347e0b3cfac5f176aa7870c https://doi.org/10.1076/brhm.29.3.286.1439 Zobrazit plný text záznamu