Stereochemical course of acylation and aldol condensation in (4S)-4-methyl-2-benzyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones

Autor:	Carmen Avendaño, M.Teresa Bartolomé, Mónica Söllhuber, Félix L. Buenadicha
Rok vydání:	1998
Předmět:	Inorganic Chemistry Acylation chemistry.chemical_compound Chemistry Stereochemistry Organic Chemistry Quinazoline Organic chemistry Aldol condensation Physical and Theoretical Chemistry Racemization Catalysis Stereocenter
Zdroj:	Tetrahedron: Asymmetry. 9:249-258
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(97)00614-9
Popis:	Acylation of 1 leads to the syn derivatives 2 . Traces of the anti isomers equilibrate to the syn isomers when stored in CHCl 3 . Aldol condensation showed great diastereoselectivity, but racemization could not be avoided. The configuration of the new introduced stereogenic centres has been assigned on the basis of 1 H-NMR data and NOE measurements.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::700a333632afd5725795ba673fb64e0b https://doi.org/10.1016/s0957-4166(97)00614-9 Zobrazit plný text záznamu Full Text from ScienceDirect