Synthesis and Nootropic Activity of new 3-Amino-12-N-Methylcytisine Derivatives

Autor:	P. R. Petrova, F. S. Zarudii, A. V. Koval’skaya, N. S. Makara, Yu. V. Vakhitova, E. I. Farafontova, Alexander N. Lobov, Inna P. Tsypysheva, L. F. Zainullina
Rok vydání:	2015
Předmět:	Chemistry Stereochemistry Plant Science General Chemistry Alkylation General Biochemistry Genetics and Molecular Biology In vitro Nootropic Cytisine chemistry.chemical_compound In vivo N-methylcytisine Cytotoxicity Lead compound
Zdroj:	Chemistry of Natural Compounds. 51:910-915
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-015-1446-x
Popis:	Reductive alkylation of 3-amino-12-N-methylcytisine by aromatic aldehydes synthesized a series of secondary amines. The nootropic activity of the synthesized compounds was studied in vivo (mnestic and antihypoxic properties) and in vitro (antiradical properties and ability to affect transcription factor HIF-1 DNA-binding activity). The cytotoxicity of the synthesized compounds was assessed. The lead compound was identified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::70080eb4bcbf04c15c4047706dd090c2 https://doi.org/10.1007/s10600-015-1446-x Zobrazit plný text záznamu Plný text ve formátu PDF